Amy Knudsen, PhD

Senior Scientist Amy Knudsen
Assistant Professor of Radiology, Harvard Medical School
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Fax: 617-726-9414
Location: Institute for Technology Assessment
Massachusetts General Hospital
101 Merrimac St., STE 1010
Boston, MA 02114

Dr. Knudsen received a BS with Distinction in policy analysis from Cornell University and a PhD in Health Policy from Harvard University. While at Harvard, Amy was the recipient of a Cancer Prevention Training Grant from the National Cancer Institute (NCI) and a Dissertation Completion Fellowship from Harvard University. She completed a NCI-funded post-doctoral fellowship in the Dana-Farber/Harvard Cancer Center Program in Cancer Outcomes Research Training (PCORT). She has worked for health-economics consulting firms where she developed decision-analytic models to assess the lifetime health and economic consequences of obesity and the benefits of weight loss.

Dr. Knudsen’s career goal is to improve cancer outcomes by identifying the most effective and cost-effective options for prevention, screening, and treatment. Her research focuses on the use of disease simulation models to inform cancer control policies. Her work to date has focused on colorectal cancer, the second most common cause of cancer death in the US. She developed and programmed a computer model, SimCRC, that simulates the natural history of colorectal cancer among the US population over time and incorporates the effects of prevention, screening, and treatment interventions. SimCRC has been used to inform both state- and national screening coverage decisions and guidelines. Dr. Knudsen’s research aims to evaluate how existing and emerging screening methodologies can best be used to minimize the burden of colorectal cancer.


  • Knudsen, A., Zauber, A. G., Rutter, C. M., Naber, S. K., Doria-Rose, V. P., Pabiniak, C., Johanson, C., Fischer, S. E., Lansdorp-Vogelaar, I. & Kuntz, K. M. (2016). Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force. JAMA, 315(23), 2595-2609. [Online version]
  • Rutter, C. M., Knudsen, A., Marsh, T. L., Doria-Rose, V. P., Johnson, E., Pabiniak, C., Kuntz, K. M., van Ballegooijen, M., Zauber, A. G. & Lansdorp-Vogelaar, I. (2016). Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications. Med Decis Making, . [Online version]
  • Goede, S. L., Kuntz, K. M., van Ballegooijen, M., Knudsen, A., Lansdorp-Vogelaar, I., Tangka, F. K., Howard, D. H., Chin, J., Zauber, A. G. & Seeff, L. C. (2015). Cost-Savings to Medicare From Pre-Medicare Colorectal Cancer Screening. Med Care, 53(7), 630-638. [Online version]
  • van der Steen, A., Knudsen, A., van Hees, F., Walter, G. P., Berger, F. G., Daguise, V. G., Kuntz, K. M., Zauber, A. G., van Ballegooijen, M. & Lansdorp-Vogelaar, I. (2015). Optimal colorectal cancer screening in states' low-income, uninsured populations-the case of South Carolina. Health Serv Res, 50(3), 768-789. [Online version]
  • Rutter, C. M., Johnson, E. A., Feuer, E. J., Knudsen, A., Kuntz, K. M. & Schrag, D. (2013). Secular Trends in Colon and Rectal Cancer Relative Survival. J Natl Cancer Inst, 105(23), 1806-13. [Online version]